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PublicationsPublications

Subtype-specific associations of steatotic liver disease with gastric and esophageal cancers: a nationwide cohort study

01/13/2026

CONCLUSIONS: GC risk is modestly increased in MASLD and more pronounced in alcohol-related SLD subtypes, whereas EC risk is primarily driven by alcohol exposure. These findings indicate that GC is influenced by both metabolic dysfunction and alcohol, while alcohol plays the predominant role in EC.

Guangdong Biobank Cohort (GDBC) study

01/13/2026

The global rise of non-communicable diseases (NCDs) presents an urgent public health challenge, particularly in regions undergoing rapid economic and demographic transitions. Guangdong Province, China's most populous and economically advanced region, is experiencing a substantial and accelerating burden of NCDs. However, large-scale, population-based cohorts from this region remain scarce, limiting insights into region-specific disease determinants and prevention strategies. The Guangdong...

Therapeutic Effects of Low-Intensity Treadmill Exercise on Motor and Non-Motor Symptoms in a 6-Hydroxydopamine (OHDA) Rat Model of Parkinson's Disease via Gut-Brain Axis Modulation

01/13/2026

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms that substantially reduce quality of life. Current pharmacological treatments primarily target motor deficits and often fail to address non-motor symptoms, underscoring the need for adjunctive strategies. The study aimed to evaluate the therapeutic potential of low-intensity treadmill exercise initiated shortly after the induction of PD using 6-hydroxydopamine (6-OHDA) in rats,...

Global Prevalence and Future Prediction of Sarcocystis Infection in Pigs: A Systematic Review and Meta-Analysis

01/13/2026

No abstract

Global Burden and Future Trends of Gastrointestinal Cancers in Adolescents and Young Adults, 1990-2045: A Predictive Analysis

01/13/2026

CONCLUSIONS: The burden of GI cancers among AYAs remains substantial and is projected to persist, highlighting the need for targeted early-detection strategies and age-specific prevention programs, especially in high-risk regions.

Assessment of automated pancreatic secretory response measurement in a cohort of pediatric patients

01/13/2026

CONCLUSION: In a clinical sample of pediatric and young adult patients, abnormal pancreatic secretory response was present in 30.8 to 34.8% of patients and was most common in patients with acute pancreatitis. Quantiative assessment identifies more patients with abnormal secretory response than qualitative assessment.

Primary splenic angiosarcoma with diffuse intrasinusoidal hepatic metastasis mimicking lymphoma: a diagnostic challenge

01/13/2026

CONCLUSION: Primary splenic angiosarcoma rarely presents with non-nodular intrasinusoidal hepatic metastasis, mimicking infiltrative liver diseases. Liver biopsy may fail to yield a definitive diagnosis. Therefore, a splenectomy may be required to establish a definitive diagnosis and guiding appropriate management when liver biopsy is inconclusive. Recognizing this uncommon metastatic pattern is crucial to avoid misdiagnosis and ensure timely treatment.

A case of isolated pancreatic sarcoidosis presenting with acute pancreatitis necessitating a differential diagnosis from pancreatic cancer

01/13/2026

No abstract

High Seropositivity for Helminths in Immunosuppressed Patients with Peripheral Eosinophilia

01/13/2026

CONCLUSION: Nearly 30% of immunosuppressed patients with peripheral eosinophilia had serological evidence of helminthic infections. Helminth serology panel testing for persistent or unexplained eosinophilia along with clinical evaluation may facilitate early diagnosis and management in immunocompromised hosts.

Corrigendum: Correlation in the change of gut microbiota with clinical periodontal parameters in grade C periodontitis patients after non-surgical periodontal therapy

01/13/2026

No abstract

Mastering Single Port Robot-Assisted Partial Nephrectomy with the Low Anterior Access: A Learning Curve Analysis with Comparison of Perioperative Outcomes

01/13/2026

Introduction: Single port (SP) robot-assisted partial nephrectomy (RAPN) can be successfully performed via an extraperitoneal low anterior access (LAA), with the patient in a supine position. To our knowledge, no data on the learning curve (LC) of SP RAPN performed with the LAA are available in the literature. Methods: Supine LAA SP RAPNs performed by a single experienced SP surgeon from 2019 to 2025 were retrospectively reviewed. A cumulative summation (CUSUM) methodology in terms of operative...

Low Dose Botulinum Toxin Injection in Retrograde Cricopharyngeal Dysfunction

01/13/2026

Retrograde cricopharyngeal dysfunction or R-CPD has a variety of symptoms including the inability to belch. Often, physical examination and additional testing reveal no abnormalities. Botulinum toxin injections into the cricopharyngeal muscle is the most described treatment in patients with R-CPD. Dosages range from 10 to 200 units, injected in one or several sites of the cricopharyngeal muscle. This study is a retrospective case series study of 3 consecutive patients referred for botulinum...

Association between plasma glucose-dependent insulinotropic polypeptide and active adiponectin in normoglycemic women

01/13/2026

CONCLUSION: An inverse association was found between postprandial GIP levels and circulating HMW-adiponectin levels in humans. This work highlights the suitability of using postprandial plasma GIP as a biomarker for metabolic disturbances of increased adiposity, even in the absence of obesity.

Solid food swallows of high-resolution manometry unmask esophageal hypomotility in GERD

01/13/2026

CONCLUSIONS: SFS unmask clinically significant esophageal dysmotility in GERD patients that SWS miss, revealing pathophysiology linked to prolonged acid exposure and mucosal injury. SFS-enhanced HRM protocols may improve GERD evaluation and risk stratification.

Novel Hemostatic Powder as Rescue Therapy for Persistent Oozing Following Endoscopic Papillectomy

01/13/2026

No abstract

Enhancing Awareness and Understanding of Predatory Journals: A Delphi-Validated Educational Video

01/12/2026

CONCLUSION: This study developed and validated an educational video to raise awareness of predatory journals. Refined through a rigorous Delphi process and audience feedback, the video meets high standards of clarity and usability, offering a valuable tool for young researchers. Future evaluations will assess its effectiveness.

Prescribing Patterns and Perceptions of Pancreatic Enzyme Replacement Therapy among Healthcare Providers: A Prospective United States Healthcare Providers Survey

01/12/2026

CONCLUSIONS: HCPs consider multiple factors when prescribing PERT for patients with EPI. HCP perceptions varied across PERT products, and Creon was favorably perceived more often compared to the other therapeutic options. Various factors may contribute to barriers to treatment and should be addressed to improve access.

Matrine functions as a tumor inhibitor to influence proliferation, metastasis and glycolysis in colorectal cancer via depending on METTL14-mediated m6A methylation of MEX3A

01/12/2026

Matrine is considered as an anti-cancer drug in a variety of cancers, including colorectal cancer (CRC). Methyltransferase-like 14 (METTL14) and Mex-3 RNA binding family member A (MEX3A) were associated with CRC progression. This study focused on the mechanism of matrine with METTL14 and MEX3A in CRC. Cell viability, proliferation, apoptosis, and migration/invasion were assessed by cell counting kit-8, EdU assay, flow cytometry, and transwell assay. Glycolysis metabolism was evaluated by glucose...

Deep learning in enhanced CT imaging: predicting invasion depth of rectal adenocarcinoma

01/12/2026

CONCLUSION: RectoDepthAI emerges as a promising tool for non-invasive staging of rectal adenocarcinoma, improving diagnostic precision and supporting clinicians in treatment decision-making.

Multi-center evaluation of radiomics and deep learning to stratify malignancy risk of IPMNs

01/12/2026

CONCLUSION: The fusion model, which combines DL with radiomics features from routine T2W MRI, shows promise for objective, cyst-level risk stratification of IPMNs in a multi-center cohort, outperforming radiomics-only models and nearly matching expert radiologists using only T2W and T1-weighted (T1W) sequences. While performance requires improvement for standalone clinical use, this approach offers a scalable, non-invasive method to potentially improve diagnostic accuracy and reduce unnecessary...
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